Wed Jul 5 09:09:18 EDT 2017 Slept from eleven to six without waking. Sunny today. High of eighty-two. Work: - Follow up on VS voicemail RTP issue Done. - Call Hazel Park about network drives Done. Thirty-minute walk at lunch. Saw a morning dove and a dragon fly. Home: - Continue to polish Danger Jaunt Done. http://jamanetwork.com/journals/jama/fullarticle/2636710 > Having come to terms with this reality, scientists have been seeking more practical approaches. They’ve increasingly become interested in fasting-based analogues to daily caloric restriction, such as time-restricted feeding, alternate-day fasting, intermittent fasting (1 fasting day or less alternated with 1 to 6 days of a normal diet), and periodic prolonged fasting (2 or more consecutive fasting days occurring periodically). > In a 2011 NIA-cofunded study of young overweight women, a weekly fast—5 days of unrestricted eating and 2 consecutive days of 75% caloric restriction—produced outcomes similar to daily caloric restriction in reducing weight, total and low-density lipoprotein (LDL) cholesterol, and blood pressure, among other markers. The fasting plans used in this study and a follow-up spawned the “5:2” diets that have gained popularity in recent years. > The results of a recent phase 2 trial published earlier this year in Science Translational Medicine suggest that less severe energy restriction could provide bigger improvements with fewer fasting days per month. In the trial, dieters only had to restrict their calories 60% for 5 consecutive days a month over 3 months to get the benefits of the so-called “fasting-mimicking diet.” > In the same study, Longo also tested the diet in a small pilot clinical trial. After 3 monthly cycles of a 5-day fasting-mimicking diet, the 19 generally healthy participants in the intervention group reported no major adverse effects and had decreased risk factors and biomarkers for aging, diabetes, cardiovascular disease, and cancer compared with the control group, which maintained its normal caloric intake. http://www.themillions.com/2017/06/on-the-education-of-henry-adams.html > Adams was essentially an autodidact, and one detects in the patterns of his thinking both the autodidact’s characteristic strengths—catholicity of interest, a tendency toward synthesis—as well as weaknesses, the primary one being an idiosyncrasy that borders at times on cranky. Lunch: cupcake, coffee, peanut butter and jelly, apple Dinner: Philly cheesesteak